Description

2'-Dicyclohexylphosphino-2,6-dimethoxy-3-sulfonato-1,1'-biphenyl hydrate sodium salt is a highly specialized, water-soluble ligand designed for advanced catalytic applications. This compound matters because it enables efficient cross-coupling reactions in aqueous or biphasic systems, offering significant advantages in process sustainability and catalyst recovery. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing greener synthetic routes.

Application

• Aqueous-Phase Cross-Coupling Catalysis: Enables Suzuki-Miyaura, Heck, and Sonogashira reactions in water, reducing organic solvent use.
• Pharmaceutical Intermediate Synthesis: A key ligand for constructing complex biaryl and heteroaryl scaffolds in API development.
• Homogeneous Catalyst Recovery: Facilitates catalyst separation and recycling in biphasic systems due to its sulfonated, water-soluble structure.
• Agrochemical Manufacturing: Used in the synthesis of advanced active ingredients requiring precise C-C bond formation.
• Fine Chemical Production: Applied in the synthesis of specialty chemicals, flavors, and fragrances where high selectivity is required.
• Academic & Industrial Research: A valuable tool for methodology development in green chemistry and catalysis.

Basic Information

Item	Details
Product Name	2'-Dicyclohexylphosphino-2,6-Dimethoxy-3-Sulfonato-1,1'-Biphenyl Hydrate Sodium Salt
CAS No.	1049726-96-6
Molecular Formula	C26H36NaO7PS · xH2O
Molecular Weight	554.57 g/mol (Anhydrous basis)
Synonyms	Sodium 2'-Dicyclohexylphosphino-2,6-dimethoxy-[1,1'-biphenyl]-3-sulfonate Hydrate; Sulfonated SPhos Sodium Salt; 2-Dicyclohexylphosphino-2',6'-dimethoxy-3-sulfonato-1,1'-biphenyl Sodium Salt; Water-Soluble SPhos Ligand; SPhos-SO3Na; Sodium 2'-(Dicyclohexylphosphino)-2,6-dimethoxybiphenyl-3-sulfonate; 2-Dicyclohexylphosphino-2',6'-dimethoxy-3-sodium sulfonato-1,1'-biphenyl.
EINECS	Contact for details

Quality Control

Our production of 2'-Dicyclohexylphosphino-2,6-dimethoxy-3-sulfonato-1,1'-biphenyl hydrate sodium salt adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and assay is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, maintain storage temperatures between 2°C and 8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Elemental Analysis	Within theoretical range

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.