Description

Simeprevir CAS NO 1042695-84-0 is a potent and selective protease inhibitor specifically designed to target the hepatitis C virus (HCV). This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacture of effective antiviral therapies. It is primarily utilized by pharmaceutical companies and research institutions engaged in antiviral drug formulation and advanced clinical studies.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of antiviral medications for Hepatitis C Virus (HCV) treatment.
• Key intermediate in advanced pharmaceutical synthesis and process development.
• Reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical research for studying HCV protease inhibition mechanisms and resistance profiles.
• Pre-clinical and clinical trial material for next-generation antiviral drug candidates.

Basic Information

Product Name	Simeprevir
CAS No.	1042695-84-0
Molecular Formula	C38H47N5O7S2
Molecular Weight	749.94 g/mol
Synonyms	TMC435; Simeprevir sodium; Olysio; TMC435350; (1R,3aR,6aS)-2-[(2S)-2-[[(2S,3S)-1-[(2S)-2-[[(2S,3S)-2-(Cyclopentylcarboxamido)-3-methylpentanoyl]amino]-3,3-dimethylbutanoyl]-3-methoxy-2-azetidinyl]formamido]-3,3-dimethylbutanoyl]-N-[(3R)-1-(cyclopropylamino)-1,2-dioxo-3-isoquinolinyl]octahydrocyclopenta[c]pyrrole-1-carboxamide
EINECS	Contact for details

Quality Control

Our Simeprevir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Chiral Purity	≥ 99.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.