Description

Benzoyl Chloride, 2,4,5-Trifluoro-3-Hydroxy- is a highly functionalized benzoyl chloride derivative, distinguished by its trifluoro and hydroxy substituents. This unique structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for synthesizing complex organic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to introduce the benzoyl moiety into target compounds under demanding conditions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the trifluoromethyl and hydroxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing high-performance, specialty polymers with unique thermal and chemical resistance properties.
• Complex Ligand Synthesis: Employed in organometallic chemistry and catalysis to create sophisticated ligands for asymmetric synthesis and metal-organic frameworks (MOFs).
• Dye & Pigment Manufacturing: Intermediate for creating fluorinated dyes and pigments that offer superior lightfastness and color properties.

Basic Information

Product Name	Benzoyl Chloride, 2,4,5-Trifluoro-3-Hydroxy-
CAS No.	1042641-60-0
Molecular Formula	C7H2ClF3O2
Molecular Weight	218.54 g/mol
Synonyms	2,4,5-Trifluoro-3-hydroxybenzoyl chloride; 3-Hydroxy-2,4,5-trifluorobenzoyl chloride; 2,4,5-Trifluoro-3-hydroxybenzoic acid chloride; (2,4,5-Trifluoro-3-hydroxyphenyl)(oxo)methaniumyl chloride
EINECS	Contact for details

Quality Control

Our Benzoyl Chloride, 2,4,5-Trifluoro-3-Hydroxy- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.