Description

Basimglurant Sulfate is a high-purity, non-competitive metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator. This compound is of significant interest for its potential therapeutic applications in central nervous system disorders. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in preclinical and clinical-stage drug discovery programs.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in drug substance and product testing.
• Preclinical Neuroscience Research: Used in in vitro and in vivo studies to investigate the role of mGluR5 in conditions such as depression, anxiety, Fragile X syndrome, and levodopa-induced dyskinesia in Parkinson's disease.
• Clinical Trial Material (CTM): Supplied as a key intermediate or active pharmaceutical ingredient (API) for the formulation of investigational medicinal products in clinical trials.
• Mechanism of Action Studies: Employed to elucidate signaling pathways and neurobiological mechanisms mediated by mGluR5 inhibition.
• Biochemical Assay Development: Acts as a critical tool compound for screening assays and high-throughput screening (HTS) campaigns targeting the mGluR5 receptor.

Basic Information

Product Name	Basimglurant Sulfate
CAS No.	1034442-21-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Basimglurant hydrogen sulfate; RO4917523; 2-Chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl)ethynyl)pyridine sulfate; mGluR5 negative allosteric modulator; AFQ056 sulfate (related compound)
EINECS	Contact for details

Quality Control

Our Basimglurant Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/UPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.