Description

4-Borono-3,5-Difluorobenzoic Acid is a high-purity, multi-functional aromatic building block containing both a boronic acid and a carboxylic acid moiety. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates, especially those requiring Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the difluoro and boronic acid groups can be leveraged to fine-tune biological activity and physicochemical properties.
• Material Science: Serves as a precursor for the creation of organic semiconductors, metal-organic frameworks (MOFs), and advanced polymers with specific electronic or structural characteristics.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes (ABPs) and molecular tags for studying enzyme function and protein interactions.
• Ligand Synthesis: Useful for preparing sophisticated ligands for catalysis, where the carboxylic acid can be used for attachment to supports or modification, and the boronic acid for dynamic covalent chemistry.

Basic Information

Product Name	4-Borono-3,5-Difluorobenzoic Acid
CAS No.	1031857-98-3
Molecular Formula	C7H5BF2O4
Molecular Weight	201.92 g/mol
Synonyms	3,5-Difluoro-4-carboxyphenylboronic Acid; 4-Borono-3,5-difluorobenzoic Acid; Benzoic acid, 4-borono-3,5-difluoro-; (3,5-Difluoro-4-carboxyphenyl)boronic Acid; 4-Carboxy-2,6-difluorophenylboronic Acid; B-(3,5-Difluoro-4-carboxyphenyl)boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Borono-3,5-Difluorobenzoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC), identity (by 1H/13C NMR, IR), and impurity profiles to ensure consistency and suitability for your synthetic applications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.