Description

(R,S)-Anatabine-2,4,5,6-D4 is a deuterium-labeled isotopologue of the tobacco alkaloid anatabine, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in mass spectrometry-based methods. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, forensic, and toxicology sectors who require precise measurement of anatabine and related compounds.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of anatabine and other alkaloids in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Metabolism Studies: Used in pharmacokinetic and pharmacodynamic research to track the absorption, distribution, metabolism, and excretion (ADME) of anatabine and its analogs.
• Forensic Toxicology: Serves as a reference standard in the analysis of nicotine-related compounds for workplace testing, doping control, and post-mortem investigations.
• Biomarker Development: Facilitates the development and validation of analytical methods for detecting tobacco alkaloid exposure as a clinical or epidemiological biomarker.
• Reference Material for Method Validation: Provides a stable, isotopically-labeled reference point to validate analytical methods, ensuring compliance with regulatory guidelines (e.g., FDA, EMA).
• Plant Biochemistry Research: Used in studies investigating the biosynthesis and metabolic pathways of alkaloids in Nicotiana species and other plants.

Basic Information

Product Name	(R,S)-Anatabine-2,4,5,6-D4
CAS No.	1020719-11-2
Molecular Formula	C10H8D4N2
Molecular Weight	164.23 g/mol
Synonyms	Anatabine-2,4,5,6-d4; (±)-Anatabine-2,4,5,6-D4; DL-Anatabine-2,4,5,6-D4; 2,3,3a,4,5,6-Hexahydro-8H-pyrano[3,2-c]pyridine-2,4,5,6-D4; (Rac)-Anatabine-2,4,5,6-D4; Deuterated Anatabine; Anatabine-d4 (2,4,5,6 positions)
EINECS	Contact for details

Quality Control

Every batch of (R,S)-Anatabine-2,4,5,6-D4 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including isotopic purity, chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment ensures the material meets the stringent requirements for use as a certified reference material in analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.