Description

Fosdevirine CAS NO 1018450-26-4 is a potent and selective antiviral compound belonging to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs). This compound is of significant value for pharmaceutical research and development, particularly in the fight against viral infections. It is primarily needed by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in antiviral drug discovery and development.

Application

• Antiviral Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel antiviral therapeutics.
• Biochemical Assays: Used as a potent inhibitor in enzymatic studies targeting viral reverse transcriptase to understand mechanism of action and resistance profiles.
• Preclinical Development: Employed in in vitro and in vivo studies to evaluate pharmacokinetics, efficacy, and toxicity of antiviral candidates.
• Pharmaceutical Intermediates: Acts as a critical synthetic intermediate in the multi-step production of complex antiviral drug substances.
• Virology Studies: Utilized in academic and industrial laboratories to investigate viral replication cycles and identify new therapeutic targets.

Basic Information

Product Name	Fosdevirine
CAS No.	1018450-26-4
Molecular Formula	C20H21FN6O4P
Molecular Weight	459.39 g/mol
Synonyms	GSK-2248761; GSK2248761; GSK 2248761; (R)-5-(6-Amino-5-((2,6-difluorobenzyl)oxy)pyrimidin-4-yl)-2-ethoxyphenyl)((S)-1-(2-fluoroethyl)-5-methyl-1H-1,2,4-triazol-3-yl)methanol; 1H-1,2,4-Triazole-3-methanol, α-(5-(6-amino-5-((2,6-difluorophenyl)methoxy)-4-pyrimidinyl)-2-ethoxyphenyl)-1-(2-fluoroethyl)-5-methyl-, (αR,3S)-
EINECS	Contact for details

Quality Control

Our Fosdevirine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.