Description

5-(3,4-Difluorophenyl)Isoxazole-3-Carboxylic Acid is a high-purity, heterocyclic carboxylic acid derivative featuring a difluorophenyl substituent, making it a valuable synthetic intermediate. This compound is critical for research and development in advanced organic synthesis, particularly in constructing complex molecular scaffolds. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers for applications in medicinal chemistry and agrochemical discovery.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting central nervous system (CNS) disorders and inflammation.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging the bioactivity of the isoxazole and fluorinated phenyl rings.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialized polymers and advanced organic materials.
• Chemical Biology Probe: Utilized in academic and industrial research to develop molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity fluorinated heterocycles.

Basic Information

Product Name	5-(3,4-Difluorophenyl)Isoxazole-3-Carboxylic Acid
CAS No.	1017513-51-7
Molecular Formula	C10H5F2NO3
Molecular Weight	225.15 g/mol
Synonyms	5-(3,4-Difluorophenyl)-1,2-oxazole-3-carboxylic acid; 5-(3,4-Difluorophenyl)isoxazole-3-carboxylic acid; 3-Isoxazolecarboxylic acid, 5-(3,4-difluorophenyl)-; 1017513-51-7; 5-(3,4-Difluorophenyl)-3-carboxyisoxazole; 3-Carboxy-5-(3,4-difluorophenyl)isoxazole
EINECS	Contact for details

Quality Control

Our 5-(3,4-Difluorophenyl)Isoxazole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.