Description

4,5-Difluoro-2-Nitrobenzoic Acid Methyl Ester is a high-purity fluorinated nitroaromatic building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), specialty agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those targeting specific enzyme pathways where the difluoro and nitro substituents are critical for bioactivity.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its aromatic fluorine chemistry for enhanced efficacy and environmental profile.
• Material Science: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials that require specific fluorinated aromatic units.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to introduce complex functionalities.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized fluorinated dyes and pigments with unique colorfastness and stability properties.

Basic Information

Product Name	4,5-Difluoro-2-Nitrobenzoic Acid Methyl Ester
CAS No.	1015433-96-1
Molecular Formula	C9H5F2NO4
Molecular Weight	217.14 g/mol
Synonyms	Methyl 4,5-difluoro-2-nitrobenzoate; 2-Nitro-4,5-difluorobenzoic acid methyl ester; Benzoic acid, 4,5-difluoro-2-nitro-, methyl ester; Methyl 2-nitro-4,5-difluorobenzoate; 4,5-Difluoro-2-nitro-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 4,5-Difluoro-2-Nitrobenzoic Acid Methyl Ester is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.