Description

(R)-Ambrisentan CAS NO 1007358-76-0 is the single enantiomer form of the potent and selective endothelin A (ETA) receptor antagonist, ambrisentan. This high-purity chiral intermediate is critical for the research and development of targeted pulmonary arterial hypertension (PAH) therapies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced chemical synthesis facilities focused on producing enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of the API Letairis® (ambrisentan) for treating pulmonary arterial hypertension (PAH).
• Research & Development: Used in preclinical and clinical studies to investigate the specific pharmacological profile of the (R)-enantiomer.
• Process Chemistry: Serves as a reference standard and starting material for developing and optimizing asymmetric synthesis routes.
• Analytical Standard: Employed as a high-purity standard for method development and validation in HPLC and chiral analysis.
• Academic Research: Utilized in biochemical studies exploring endothelin receptor signaling pathways and structure-activity relationships (SAR).

Basic Information

Product Name	(R)-Ambrisentan
CAS No.	1007358-76-0
Molecular Formula	C22H22N2O4
Molecular Weight	378.42 g/mol
Synonyms	(R)-Ambrisentan; (2R)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic Acid; (R)-(-)-Ambrisentan; BSF 208075 (R)-enantiomer; LU 208075 (R)-enantiomer; (R)-Form of Ambrisentan; (R)-BSF 208075; (R)-LU 208075
EINECS	Contact for details

Quality Control

Our (R)-Ambrisentan is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.