Description

Cobicistat CAS NO 1004316-88-4 is a potent and selective mechanism-based inhibitor of cytochrome P450 3A (CYP3A) enzymes, functioning as a pharmacokinetic enhancer. Its primary value lies in significantly boosting the systemic exposure and efficacy of co-administered drugs that are metabolized by CYP3A, thereby improving therapeutic outcomes. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing antiretroviral therapies, particularly for the treatment of HIV-1 infection.

Application

• Pharmaceutical Ingredient: Critical active pharmaceutical ingredient (API) in fixed-dose combination antiretroviral therapies.
• HIV Treatment: Used as a pharmacoenhancer in regimens containing protease inhibitors (e.g., atazanavir, darunavir) to increase their bioavailability and reduce dosing frequency.
• Drug Development: Employed in preclinical and clinical research to study drug-drug interactions and optimize pharmacokinetic profiles of new chemical entities.
• Formulation Research: Key component in the development of novel oral solid dosage forms, such as tablets and capsules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Biochemical Research: Tool compound for in vitro studies investigating CYP3A enzyme inhibition and metabolic pathways.

Basic Information

Product Name	Cobicistat
CAS No.	1004316-88-4
Molecular Formula	C₄₀H₅₃N₇O₅S₂
Molecular Weight	776.02 g/mol
Synonyms	GS-9350; 1,3-Thiazol-5-ylmethyl N-[(1R)-1-[(2R)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl]-2-[(2-methyl-1,3-thiazol-4-yl)methyl]-3-oxo-1,2,3,6,7,8-hexahydro-4H-5,1,2-benzoxathiazocin-4-yl]carbamate; (R)-N-((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)-2-((S)-2-(methoxycarbonylamino)-3,3-dimethylbutanamido)propenamide; Tybost (brand name); CYP3A inhibitor; Pharmacokinetic enhancer
EINECS	Contact for details

Quality Control

Our Cobicistat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and MS, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) documenting compliance with relevant in-house or client-specific specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a dry environment with minimal humidity exposure. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.