Description

2,2,2-Trifluoroacetophenone-4-Boronic Acid Pinacol Ester is a high-value, multifunctional organoboron building block essential for modern synthetic chemistry. Its core value lies in combining the unique electronic properties of a trifluoromethyl ketone with the versatile reactivity of a protected boronic acid, enabling efficient cross-coupling reactions. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex fluorinated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those incorporating bioisosteric trifluoromethyl groups to enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluorinated aromatic moiety can improve lipophilicity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated organic semiconductors and charge-transport materials used in display and lighting technologies.
• Polymer Chemistry: Enables the incorporation of boronic ester functional groups into polymer backbones or side chains for creating stimuli-responsive or self-healing materials.
• Chemical Biology & Probe Development: Utilized in synthesizing activity-based probes and fluorogenic substrates for studying enzyme activity and cellular processes.
• Catalyst Ligand Synthesis: Acts as a precursor for synthesizing novel bidentate or monodentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	2,2,2-Trifluoroacetophenone-4-Boronic Acid Pinacol Ester
CAS No.	1004294-77-2
Molecular Formula	C14H16BF3O3
Molecular Weight	300.09 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2,2-trifluoroacetophenone; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone; 4-Borono-2,2,2-trifluoroacetophenone pinacol ester; 4-(2,2,2-Trifluoroacetyl)phenylboronic acid pinacol ester; TFAP-BPin; (4-(2,2,2-Trifluoroacetyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroacetophenone-4-Boronic Acid Pinacol Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistent performance in sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis of the boronic ester moiety and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.