Description

3-Amino-4-Fluorophenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. Its primary value lies in serving as a key, air-stable building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis. The pinacol ester protection enhances stability, making it a reliable and convenient reagent for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates containing biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED emitters and charge transport layers, where precise molecular architecture is key.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Probe Design: Utilized to create molecular probes and bioconjugates for studying biological processes and target engagement.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries in medicinal chemistry campaigns.

Basic Information

Product Name	3-Amino-4-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	1003575-43-6
Molecular Formula	C12H17BFNO2
Molecular Weight	237.08 g/mol
Synonyms	(3-Amino-4-fluorophenyl)boronic acid pinacol ester; 4-Fluoro-3-aminophenylboronic acid pinacol ester; 2-(3-Amino-4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 3-Amino-4-fluorobenzeneboronic acid pinacol ester; NSC 1139277; B-(3-Amino-4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 3-Amino-4-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.