Description

2′-Dicyclohexylphosphino-2,4,6-Trimethoxybiphenyl is a specialized, high-value phosphine ligand widely used in modern synthetic chemistry. Its primary value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require robust catalytic systems for challenging transformations.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination and Suzuki-Miyaura coupling for C-N and C-C bond formation.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and scalable production of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective coupling steps.
• Materials Science Research: Facilitates the creation of conjugated polymers, organic semiconductors, and other functional materials via metal-catalyzed polymerization.
• Process Chemistry & Scale-Up: Provides reliable performance in transitioning from laboratory-scale discovery to industrial manufacturing.
• Academic & Industrial R&D: A staple reagent in method development and catalysis research for discovering new synthetic pathways.

Basic Information

Product Name	2′-Dicyclohexylphosphino-2,4,6-Trimethoxybiphenyl
CAS No.	1000171-05-0
Molecular Formula	C27H37O3P
Molecular Weight	440.56 g/mol
Synonyms	2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl (common alias); RuPhos (common trade name); 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl; Dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine; RuPhos Ligand; CPhos (context-dependent); Buchwald Phosphine Ligand; 2-(Dicyclohexylphosphino)-2',6'-dimethoxybiphenyl (related structure)
EINECS	Contact for details

Quality Control

Our 2′-Dicyclohexylphosphino-2,4,6-Trimethoxybiphenyl is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should only be opened in an inert environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.