Description

(2R,4S)-1-tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate is a high-purity, chiral pyrrolidine derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its defined stereochemistry and protected functional groups make it an invaluable building block for constructing complex, biologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical development teams engaged in the synthesis of novel APIs, peptidomimetics, and other fine chemicals where precise stereocontrol is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders.
• Peptidomimetics Synthesis: Used to introduce constrained pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands and organocatalysts.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore novel chemical spaces for drug discovery.
• Custom Synthesis & Contract Manufacturing: A specified intermediate for custom synthesis projects requiring high stereochemical purity and reliable supply.
• Academic Research: Used in university and institutional labs for methodological development in stereoselective synthesis.

Basic Information

Item	Details
Product Name	(2R,4S)-1-tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate
CAS No.	198969-28-7
Molecular Formula	C18H23NO6
Molecular Weight	349.38 g/mol
Synonyms	(2R,4S)-1-Boc-2-Methyl 4-(Benzoyloxy)pyrrolidine-1,2-dicarboxylate; 1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-4-(benzoyloxy)pyrrolidine (2R,4S)-; (2R,4S)-4-Benzoyloxy-1-Boc-pyrrolidine-2-carboxylic acid methyl ester; (2R,4S)-1-N-Boc-2-COOMe-4-OBz-pyrrolidine; (2R,4S)-1-tert-Butoxycarbonyl-2-methoxycarbonyl-4-benzoyloxypyrrolidine; 1-Boc-2-Me-4-OBz-pyrrolidine-(2R,4S)-dicarboxylate; 4-Benzoyloxyproline derivative (protected); Chiral Boc-protected pyrrolidine ester
EINECS	Contact for details

Quality Control

Our (2R,4S)-1-tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity consistent with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.