Description

Merimepodib is a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo guanine nucleotide biosynthesis pathway. This targeted mechanism of action makes it a valuable intermediate in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of antiviral and immunosuppressive therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting viral infections.
• Antiviral Drug Research: Used in preclinical and clinical research for developing treatments against hepatitis C virus (HCV) and other viral diseases.
• Immunology Studies: Employed as a research tool to study lymphocyte proliferation and immune response modulation due to its IMPDH inhibition.
• Biochemical Assay Standard: Serves as a reference standard in enzymatic assays to evaluate IMPDH activity and screen for novel inhibitors.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for nucleotide analog pharmaceuticals.

Basic Information

Product Name	Merimepodib
CAS No.	198821-38-4
Molecular Formula	C₂₀H₂₀N₆O₃
Molecular Weight	392.41 g/mol
Synonyms	VX-497; Merimepodib free base; (E)-2-(3,5-Dimethyl-4-((3-methyl-4-(6-methyl-3-pyridinyl)-5-isoxazolyl)ethynyl)phenoxy)acetic acid; 4-(2-Carboxymethoxy-4,6-dimethylphenylethynyl)-5-methyl-3-(6-methylpyridin-3-yl)isoxazole; IMPDH Inhibitor VX-497
EINECS	Contact for details

Quality Control

Our Merimepodib is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that include HPLC purity, chiral purity (where applicable), and residual solvent analysis, meeting the stringent requirements for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.