Description

(S)-(+)-1,2-Propanediol ((S)-(+)-Propyleneglycerol) CAS NO 198333-86-7 is the high-purity enantiomer of propylene glycol, distinguished by its specific (S)-(+) stereochemistry. This optical purity makes it a critical chiral building block and solvent for advanced pharmaceutical synthesis and high-value specialty chemical manufacturing. It is essential for industries requiring precise stereochemical control, such as pharmaceutical intermediates, asymmetric catalysis, and fine chemical research.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Serves as a key starting material or resolving agent for producing single-enantiomer active pharmaceutical ingredients (APIs).
• Asymmetric Catalyst and Ligand Preparation: Used in the development and manufacture of chiral catalysts and ligands for stereoselective reactions.
• High-Purity Solvent for Sensitive Formulations: Acts as a chiral solvent or co-solvent in research and production where stereochemical integrity is paramount.
• Fine Chemical and Specialty Product Manufacturing: Employed in the synthesis of fragrances, flavors, and advanced materials that require specific optical activity.
• Biochemical and Diagnostic Reagents: Utilized in the preparation of chiral standards, reagents, and buffers for analytical and diagnostic applications.
• Academic and Industrial R&D: A valuable reagent for method development and research in organic chemistry and process chemistry.

Basic Information

Product Name	(S)-(+)-1,2-Propanediol ((S)-(+)-Propyleneglycerol)
CAS No.	198333-86-7
Molecular Formula	C3H8O2
Molecular Weight	76.09 g/mol
Synonyms	(S)-(+)-Propylene Glycol; (S)-Propane-1,2-diol; (S)-1,2-Dihydroxypropane; (S)-(+)-1,2-Propylene Glycol; L-Propylene Glycol; (S)-Methyl ethylene glycol; (2S)-Propane-1,2-diol; Optically Active Propylene Glycol
EINECS	Contact for details

Quality Control

Our (S)-(+)-1,2-Propanediol is produced under stringent quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through advanced analytical techniques including chiral HPLC, optical rotation measurement, and standard pharmacopeial tests. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Recommended storage temperature is between 15°C and 25°C.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]20/D	+15.0° to +16.0° (c=1, H2O)
Water Content (Karl Fischer)	≤ 0.5%
Refractive Index (n20/D)	1.432 - 1.434
Specific Gravity (20/20°C)	1.035 - 1.040

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.