Description

Methyl 2-Chloro-4-(Trifluoromethyl)Benzoate is a high-purity fluorinated aromatic ester building block essential for advanced organic synthesis. This compound is valued for its trifluoromethyl and chloro substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and hydrolysis reactions to introduce the 2-chloro-4-(trifluoromethyl)benzoyl moiety into more complex molecular architectures.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for method development, library synthesis, and exploring new chemical spaces in medicinal and material chemistry.

Basic Information

Product Name	Methyl 2-Chloro-4-(Trifluoromethyl)Benzoate
CAS No.	192805-96-2
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-toluic acid methyl ester; Methyl 2-chloro-α,α,α-trifluoro-p-toluate; Benzoic acid, 2-chloro-4-(trifluoromethyl)-, methyl ester; Methyl 2-chloro-4-trifluoromethylbenzoate; 2-Chloro-4-(trifluoromethyl)benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-4-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.