Description

Lopinavir is a potent and selective protease inhibitor, specifically designed to target the human immunodeficiency virus (HIV). This active pharmaceutical ingredient (API) is a critical component in combination antiretroviral therapy (cART), essential for managing HIV-1 infection and improving patient outcomes. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antiviral medications.

Application

• Antiretroviral Drug Formulation: As the primary active ingredient in fixed-dose combination tablets, most notably with Ritonavir.
• HIV-1 Treatment: Core component of combination therapy regimens for both treatment-naïve and treatment-experienced patients.
• Pediatric HIV Formulations: Used in the development of oral solutions and pellets suitable for pediatric patients.
• Pharmaceutical Research: Serves as a reference standard and key material in bioavailability, bioequivalence, and pharmacokinetic studies.
• Drug Development: Investigated in research for novel drug delivery systems and potential new combination therapies.
• Generic Drug Manufacturing: Essential API for companies producing generic versions of branded antiretroviral medications.

Basic Information

Product Name	Lopinavir
CAS No.	192725-17-0
Molecular Formula	C37H48N4O5
Molecular Weight	628.80 g/mol
Synonyms	ABT-378; Lopinavirum; (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; LPV; Kaletra (brand name combination with Ritonavir)
EINECS	Contact for details

Quality Control

Our Lopinavir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with current pharmacopeial standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, well-ventilated area. For long-term stability, store under an inert atmosphere if the container is opened frequently.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.