Description

(S)-(-)-2,2'-Bis[Bis(3,5-Dimethylphenyl)Phosphino]-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl is a high-value, chiral phosphine ligand crucial for enabling highly selective asymmetric catalytic transformations. Its primary commercial value lies in its ability to impart exceptional enantioselectivity and activity in the synthesis of complex chiral molecules, which is a cornerstone of modern pharmaceutical and fine chemical manufacturing. This ligand is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing single-enantiomer active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Catalyzes key reactions like cross-coupling, allylic alkylation, and conjugate additions with high stereoselectivity for building complex molecular architectures.
• Pharmaceutical Intermediate Synthesis: Used in the production of chiral drugs for therapeutic areas including oncology, cardiology, and central nervous system disorders.
• Agrochemical Synthesis: Enables the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Fine Chemical and Flavor/Fragrance Production: Facilitates the synthesis of high-value chiral compounds used in flavors, fragrances, and specialty materials.
• Academic and Industrial R&D: A vital tool for process chemists and researchers developing new catalytic methodologies and optimizing synthetic routes.

Basic Information

Product Name	(S)-(-)-2,2'-Bis[Bis(3,5-Dimethylphenyl)Phosphino]-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl
CAS No.	190003-83-9
Molecular Formula	C60H60P2
Molecular Weight	819.07 g/mol
Synonyms	(S)-H8-BINAP(DM); (S)-(-)-5,5',6,6',7,7',8,8'-Octahydro-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; (S)-H8-BINAP(3,5-Me); (S)-Octahydro-BINAP(DM); (S)-H8-BINAP(3,5-Me); (S)-H8-BINAP(3,5-Me2Ph); (S)-H8-BINAP(3,5-Dimethylphenyl); (S)-2,2'-Bis(di-3,5-xylylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl
EINECS	Contact for details

Quality Control

Our (S)-(-)-2,2'-Bis[Bis(3,5-Dimethylphenyl)Phosphino]-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high catalytic performance. All products undergo rigorous analytical testing, including chiral HPLC, 31P NMR, and elemental analysis, to verify identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air or ambient light should be avoided to maintain catalytic activity. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
31P NMR	Conforms to reference
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.