Description

2-Nitro-5-(Trifluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its nitro and trifluoromethoxy substituents. This compound is essential for the synthesis of complex molecules, offering unique electronic and steric properties that are difficult to achieve with other intermediates. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring the trifluoromethoxy pharmacophore for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the nitro and trifluoromethoxy groups contribute to target specificity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, where its molecular structure aids in tuning the electro-optical properties of displays and lighting components.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific characteristics such as chemical resistance, thermal stability, or unique surface properties.
• Organic Synthesis & Research: A versatile reagent in academic and industrial R&D labs for constructing complex heterocycles and conducting structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Nitro-5-(Trifluoromethoxy)Benzoic Acid
CAS No.	189359-65-7
Molecular Formula	C8H4F3NO5
Molecular Weight	251.12 g/mol
Synonyms	5-(Trifluoromethoxy)-2-nitrobenzoic acid; 2-Nitro-5-trifluoromethoxybenzoic acid; Benzoic acid, 2-nitro-5-(trifluoromethoxy)-; 189359-65-7; 2-Nitro-α,α,α-trifluoro-p-anisic acid; 2-Nitro-5-(trifluoromethoxy)benzenecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Nitro-5-(Trifluoromethoxy)Benzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥97% by HPLC), and impurity profile is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.