Description

Bohemine CAS NO 189232-42-6 is a selective and potent inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK2. This compound matters as a crucial research tool for studying cell cycle regulation, apoptosis, and signal transduction pathways in various disease models. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurodegenerative diseases, and anti-aging research.

Application

• Biochemical Research: Used as a selective CDK2 inhibitor to investigate cell cycle control mechanisms and protein kinase functions in vitro.
• Oncology Studies: Employed in cancer research to study tumor cell proliferation, apoptosis induction, and the development of targeted cancer therapies.
• Neurodegenerative Disease Research: Applied in models of Alzheimer's and Parkinson's disease to explore the role of cell cycle dysregulation in neuronal death.
• Anti-Aging & Senescence Research: Utilized to study cellular senescence and aging processes, helping to identify potential therapeutic interventions.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the discovery and optimization of novel CDK-inhibiting drugs.
• Academic & Institutional Labs: A key reagent for graduate and post-doctoral research in molecular biology, biochemistry, and pharmacology departments.

Basic Information

Product Name	Bohemine
CAS No.	189232-42-6
Molecular Formula	C19H18N6O
Molecular Weight	346.39 g/mol
Synonyms	Bohemine; (E)-N-[4-[[(6,7-Dimethoxy-4-quinazolinyl)amino]methyl]phenyl]-3-pyridinecarboxamide; CDK2 Inhibitor III; CGP 79807; 6,7-Dimethoxy-2-((4-(3-pyridinylcarbamoyl)benzyl)amino)quinazoline; BHM; CAS 189232-42-6
EINECS	Contact for details

Quality Control

Our Bohemine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be kept at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.