Description

6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-[(1R,3S,4R)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl]- is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of novel antiviral and anticancer therapeutics. It is primarily needed by pharmaceutical companies, biotechnology research institutes, and contract development and manufacturing organizations (CDMOs) engaged in cutting-edge drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside-based antiviral drugs.
• Antiviral Research: Investigated for activity against a range of viral targets, including hepatitis and herpes viruses.
• Oncology Drug Discovery: Used in research for developing novel chemotherapeutic agents that target DNA synthesis.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to purine metabolism.
• Pre-clinical Development: Utilized in formulation studies and pharmacokinetic profiling of new drug candidates.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-[(1R,3S,4R)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl]-
CAS No.	188399-46-4
Molecular Formula	C12H15N5O3
Molecular Weight	277.28 g/mol
Synonyms	9-[(1R,3S,4R)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine; 2-Amino-9-[(1R,3S,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-1,9-dihydro-6H-purin-6-one; (1'R,2'S,3'R)-9-(2',3'-Dihydroxy-4'-methylenecyclopent-1'-yl)guanine; Cyclopentyl Guanosine Analog; Antiviral Nucleoside Intermediate; 188399-46-4; 2-Amino-9-(4-hydroxy-3-hydroxymethyl-2-methylenecyclopentyl)-1,9-dihydro-purin-6-one
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development needs with custom purity grades and specifications aligned with cGMP standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.