Description

Rimeporide Hydrochloride is a selective and potent inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1), a key target in cardioprotection and fibrosis research. This high-purity compound is critical for preclinical and pharmaceutical development, offering researchers a reliable tool to investigate pathways related to heart failure, ischemia-reperfusion injury, and tissue remodeling. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on developing novel therapeutics for cardiovascular and fibrotic diseases.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel cardioprotective and anti-fibrotic drugs.
• Preclinical Research: Used in in vitro and in vivo studies to elucidate the role of NHE-1 in cardiac ischemia-reperfusion injury, myocardial infarction, and heart failure.
• Biochemical Assay Development: Employed as a potent inhibitor to validate and optimize high-throughput screening assays targeting the NHE-1 transporter.
• Mechanistic Studies: Facilitates research into cellular signaling pathways involving intracellular pH regulation, sodium overload, and their connection to cellular injury and death.
• Fibrosis Research: Investigated for its potential therapeutic effects in models of organ fibrosis, including pulmonary, renal, and hepatic fibrosis.
• Academic Research: A vital tool for universities and research institutes studying cardiovascular physiology, pharmacology, and pathophysiology.

Basic Information

Product Name	Rimeporide Hydrochloride
CAS No.	187870-95-7
Molecular Formula	C20H24N4O3S • HCl
Molecular Weight	436.96 g/mol
Synonyms	4-Methyl-2-((4-((methylsulfonyl)oxy)piperidin-1-yl)sulfonyl)benzoic acid hydrochloride; Rimeporide HCl; NHE-1 Inhibitor; EMD-87580; (4-Methyl-2-((4-((methylsulfonyl)oxy)piperidin-1-yl)sulfonyl)benzoic acid, hydrochloride)
EINECS	Contact for details

Quality Control

Our Rimeporide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and impurities to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.