Description

Rimeporide is a potent and selective inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1), a key therapeutic target for cardiac and fibrotic diseases. This high-purity compound is essential for pharmaceutical research and development, enabling the study of cardioprotective mechanisms and the advancement of novel treatments. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in preclinical studies for heart failure, myocardial infarction, and other conditions involving cellular sodium overload and fibrosis.

Application

• Cardioprotective Research: Investigation of mechanisms to reduce ischemia-reperfusion injury and myocardial infarction damage.
• Anti-fibrotic Drug Discovery: Target validation and efficacy studies in models of cardiac, pulmonary, and renal fibrosis.
• Preclinical Pharmacology: In vitro and in vivo studies to establish pharmacokinetic and pharmacodynamic profiles for drug candidates.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) to identify new NHE-1 modulators.
• Academic Research: Fundamental studies on ion transport physiology and cellular signaling pathways in disease states.

Basic Information

Product Name	Rimeporide
CAS No.	187870-78-6
Molecular Formula	C15H16F3N3O3S
Molecular Weight	375.36 g/mol
Synonyms	4-Methyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine; EMD-87580; (4-Methyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-2-yl)-(4-trifluoromethanesulfonyl-phenyl)-amine; NHE-1 Inhibitor; Cariporide analog; Benzylsulfonyl derivative
EINECS	Contact for details

Quality Control

Our Rimeporide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible results for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.