Description

L-Glutamine-[3,4-3H] is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-glutamine, designed for advanced biochemical research. This radiolabeled compound is critical for precise metabolic pathway tracing, receptor binding studies, and pharmacokinetic research where high sensitivity is required. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on oncology, neurology, and metabolic disease studies.

Application

• Metabolic Flux Analysis: Tracing glutamine utilization in cancer cell metabolism (e.g., glutaminolysis) and other metabolic pathways.
• Receptor Binding & Uptake Studies: Investigating the kinetics and specificity of glutamine transporters (e.g., ASCT2, SNAT family) in various cell types.
• Protein Synthesis & Turnover Research: Measuring rates of protein synthesis in cell culture and tissue samples.
• Pharmacokinetic (PK) & Absorption, Distribution, Metabolism, and Excretion (ADME) Studies: Radiolabeled tracking of glutamine or glutamine-conjugated drug candidates in preclinical models.
• Biochemical Assay Development: Serving as a tracer in enzymatic assays for glutamine-utilizing enzymes like glutaminase or glutamine synthetase.
• Autoradiography & Imaging: Used in tissue section autoradiography to localize sites of active glutamine metabolism.

Basic Information

Product Name	L-Glutamine-[3,4-3H]
CAS No.	186144-07-0
Molecular Formula	C5H103H2N2O3
Molecular Weight	~149.1 g/mol (varies with specific activity)
Synonyms	(2S)-2-Amino-4-carbamoyl-[3,4-3H]butanoic acid; L-Glutamine-3,4-t; Tritiated L-Glutamine; [3,4-3H]-L-Gln; L-Glutamine (3,4-t); Glutamine-3,4-t2; H-Gln-OH-3,4-t2
EINECS	Contact for details

Quality Control

Every batch of L-Glutamine-[3,4-3H] is manufactured and analyzed under strict quality systems. We provide comprehensive analytical documentation to ensure traceability and reliability for your critical research. Certificates of Analysis (COA) are supplied with each shipment, detailing key parameters such as radiochemical purity, specific activity, chemical purity, and solvent composition. Our quality commitment aligns with the standards expected in pharmaceutical and high-level academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at ≤ -20°C or as recommended on the specific product label. Store in accordance with all local and national regulations for radioactive materials. Allow the product to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC, TLC)	Conforms to reference standard
Specific Activity	Contact for details (typically 40-80 Ci/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent	Aqueous ethanol or specified buffer
Concentration	1 mCi/mL (typical, as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.