Description

2,6-Bis[(4R)-4-tert-Butyl-2-Oxazolin-2Yl]Pyridine is a high-purity, chiral ligand belonging to the bis(oxazoline) (BOX) family, a cornerstone in modern asymmetric synthesis. Its value lies in its ability to form highly selective and active complexes with various transition metals, enabling precise control over stereochemistry in critical bond-forming reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance catalysts for developing enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for copper(I), iron(II), nickel(II), and other transition metals in enantioselective reactions.
• Pharmaceutical Synthesis: Key component in the production of chiral drug candidates and APIs, particularly for cyclopropanation, Diels-Alder, and aldol reactions.
• Agrochemical Development: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Enables the synthesis of complex, high-value chiral molecules for flavors, fragrances, and specialty materials.
• Academic & Industrial R&D: A critical tool for method development and discovery chemistry in asymmetric synthesis laboratories.
• Material Science: Potential use in the development of chiral polymers and metal-organic frameworks (MOFs) with specific optical properties.

Basic Information

Product Name	2,6-Bis[(4R)-4-tert-Butyl-2-Oxazolin-2Yl]Pyridine
CAS No.	185346-17-2
Molecular Formula	C21H31N3O2
Molecular Weight	357.49 g/mol
Synonyms	(R,R)-2,6-Bis(4-tert-butyl-2-oxazolin-2-yl)pyridine; (R,R)-2,6-Bis(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine; (R,R)-t-Bu-PyBOX; (4R,4'R)-2,6-Bis(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine; Pyridine, 2,6-bis[(4R)-4-(1,1-dimethylethyl)-4,5-dihydro-2-oxazolyl]-; (R,R)-2,6-Bis(4-tert-butyl-2-oxazolinyl)pyridine; BOX Ligand (tert-butyl substituted); Chiral PyBOX Ligand
EINECS	Contact for details

Quality Control

Our 2,6-Bis[(4R)-4-tert-Butyl-2-Oxazolin-2Yl]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and elemental analysis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and full specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent degradation upon repeated opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.