Description

34-Hydroxy Sirolimus is a significant hydroxylated derivative of the potent immunosuppressant and mTOR inhibitor, Sirolimus. This compound is primarily valued as a key intermediate or reference standard in advanced pharmaceutical research and development. It is essential for scientists and manufacturers in the biotechnology and pharmaceutical industries focused on developing novel therapeutics, particularly in the fields of oncology, immunosuppression, and anti-aging research.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthetic pathways for novel mTOR inhibitor drugs and prodrugs.
• Biochemical Research: Used as a reference standard or analytical standard in pharmacokinetic and metabolic studies of Sirolimus and its analogs.
• Mechanistic Studies: Employed in research to investigate the structure-activity relationship (SAR) of Sirolimus derivatives and their interaction with the mTOR pathway.
• API Development: Acts as a precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) targeting immunosuppression and cancer.
• Metabolite Identification: Utilized as an authentic standard for the identification and quantification of Sirolimus metabolites in biological matrices.

Basic Information

Product Name	34-Hydroxy Sirolimus
CAS No.	185107-79-3
Molecular Formula	C51H79NO14
Molecular Weight	930.17 g/mol
Synonyms	34-Hydroxy Rapamycin; 34-Hydroxy Sirolimus; 34-Hydroxy-AY-22989; 34-Hydroxyrapamycin; 34-OH-Rapamycin; 34-OH-Sirolimus; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
EINECS	Contact for details

Quality Control

Our 34-Hydroxy Sirolimus is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the certificate of analysis. This product is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Maximum Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.