Description

D-Mannitol, 1,4:3,6-Dianhydro-2-o-(Phenylmethyl)- is a specialized, high-value derivative of mannitol, a sugar alcohol, characterized by its bicyclic dianhydro structure and a benzyl ether protecting group. This compound is a critical pharmaceutical intermediate and chiral building block used in the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for research and production in the pharmaceutical, biotechnology, and advanced organic synthesis sectors, where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly for antiviral, anticancer, and neurological therapies.
• Chiral Auxiliary/Resolution Agent: Utilized in asymmetric synthesis to induce or control stereoselectivity in the formation of new chiral centers.
• Protecting Group Chemistry: The benzyl ether moiety serves as a temporary protecting group for hydroxyl functions during complex synthetic sequences.
• Research & Development: Serves as a standard or starting material in medicinal chemistry and process development labs for exploring new synthetic routes.
• Fine Chemical Synthesis: Used in the production of specialty chemicals, advanced materials, and ligands for catalysis.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	D-Mannitol, 1,4:3,6-Dianhydro-2-o-(Phenylmethyl)-
CAS No.	183624-93-3
Molecular Formula	C13H16O5
Molecular Weight	252.26 g/mol
Synonyms	1,4:3,6-Dianhydro-2-O-benzyl-D-mannitol; 2-O-Benzyl-1,4:3,6-dianhydro-D-mannitol; Benzyl 1,4:3,6-dianhydro-D-mannitol ether; 2-O-Benzylisomannide; Isomannide 2-benzyl ether; Dianhydro-D-mannitol benzyl ether; (3R,3aR,6R,6aR)-6-(Benzyloxy)hexahydrofuro[3,2-b]furan-3-ol
EINECS	Contact for details

Quality Control

Our D-Mannitol, 1,4:3,6-Dianhydro-2-o-(Phenylmethyl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.