Description

5,6-Dihydro Uracil-13C15N2 is a stable isotope-labeled analog of 5,6-dihydrouracil, a key intermediate in pyrimidine metabolism. This compound is essential for advanced research and development in metabolic pathway analysis and pharmacokinetic studies, providing critical internal standards for mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug metabolism and stable isotope tracer techniques.

Application

• As an internal standard for the quantitative analysis of uracil and related metabolites via LC-MS/MS and GC-MS.
• In metabolomics research to study pyrimidine catabolism and nucleotide salvage pathways.
• For pharmacokinetic (PK) studies and drug metabolism investigations to track the fate of labeled drug candidates.
• In the development and validation of clinical diagnostic assays for inborn errors of metabolism.
• As a critical reagent in isotope dilution mass spectrometry (IDMS) for achieving high analytical accuracy and precision.
• For biochemical research involving dihydropyrimidine dehydrogenase (DPD) enzyme activity and fluoropyrimidine drug response.

Basic Information

Product Name	5,6-Dihydro Uracil-13C15N2
CAS No.	181516-96-1
Molecular Formula	C313C1H6N115N1O2
Molecular Weight	116.07 g/mol (for labeled form)
Synonyms	5,6-Dihydro-2,4(1H,3H)-pyrimidinedione-13C,15N2; Dihydrouracil-13C,15N2; 5,6-Dihydrouracil-13C,15N2; [13C,15N2]-5,6-Dihydrouracil; Isotopically labeled dihydrouracil; Stable isotope labeled DHU; 2,4-Dihydroxypyrimidine-5,6-d2-13C,15N2 (related structure)
EINECS	Contact for details

Quality Control

Our 5,6-Dihydro Uracil-13C15N2 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant guidelines for the production of stable isotope-labeled compounds for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to labeled structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.