Description

4-Cyano-2,6-Difluorobenzoic Acid is a high-value, multi-functional aromatic building block characterized by its benzoic acid core substituted with cyano and fluorine groups. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring difluorobenzene and benzoic acid motifs.
• Agrochemical Synthesis: Used in the development of modern herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organic synthesis.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its conjugated system and polar functional groups.
• Custom Synthesis & Contract Manufacturing: A versatile building block for custom chemical synthesis and scale-up projects under cGMP or ISO standards.
• Academic & Industrial R&D: Utilized in research laboratories for method development and exploring new chemical reactions involving fluorinated aromatics.

Basic Information

Product Name	4-Cyano-2,6-Difluorobenzoic Acid
CAS No.	181073-82-5
Molecular Formula	C8H3F2NO2
Molecular Weight	183.11 g/mol
Synonyms	2,6-Difluoro-4-cyanobenzoic Acid; Benzoic acid, 4-cyano-2,6-difluoro-; 4-Cyano-2,6-difluorobenzoic acid; 2,6-Difluoro-4-cyanobenzoic acid; 181073-82-5; 4-Carboxy-3,5-difluorobenzonitrile; 3,5-Difluoro-4-carboxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Cyano-2,6-Difluorobenzoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed batch-specific results are available upon request. We support development and commercial projects requiring compliance with various pharmacopeial or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.