Description

(R)-9-[2-(Diethylphosphonomethoxy)Propyl] Adenine is a chiral, nucleoside phosphonate derivative of adenine, representing a key advanced pharmaceutical intermediate. This compound is of significant commercial interest due to its role as a precursor in the synthesis of novel antiviral and anticancer nucleotide analogs. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing targeted therapeutic agents, particularly for antiviral applications.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleotide reverse transcriptase inhibitors (NRTIs) and other antiviral prodrugs.
• Antiviral Drug Research: Serves as a key precursor in the development of novel therapeutic agents targeting viruses such as HIV, hepatitis B (HBV), and herpes viruses.
• Anticancer Agent Development: Used in research for creating nucleotide analogs that target cellular DNA polymerases in oncology.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and polymerase function.
• Prodrug Synthesis: Utilized in the design and synthesis of phosphonate-based prodrugs with enhanced cellular uptake and bioavailability.
• Chiral Building Block: The (R)-enantiomer provides stereochemical specificity for creating optically active pharmaceutical compounds.

Basic Information

Product Name	(R)-9-[2-(Diethylphosphonomethoxy)Propyl] Adenine
CAS No.	180587-75-1
Molecular Formula	C15H26N5O4P
Molecular Weight	371.38 g/mol
Synonyms	(R)-PMPA Prodrug Intermediate; (R)-9-(2-Phosphonylmethoxypropyl)adenine Diethyl Ester; (R)-GS-7340 Intermediate; (R)-Tenofovir Alafenamide Precursor; (R)-9-[2-(Bis(ethoxy)phosphoryl)methoxy]propyl]adenine; (R)-DPMEA; (R)-Diethyl P-MPA
EINECS	Contact for details

Quality Control

Our (R)-9-[2-(Diethylphosphonomethoxy)Propyl] Adenine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.