Description

1(S)-Phenyl-1,2,3,4-Tetrahydroisoquinoline-2-Carboxylic Acid 3(R)-Quinuclidinyl Ester Monosuccinate ([R-(R*,R*)]-Isomer, Monohcl Salt) is a high-purity, stereochemically defined pharmaceutical intermediate of significant importance in modern medicinal chemistry. This compound matters as a critical chiral building block for the research and development of novel therapeutic agents, particularly those targeting the central nervous system. Pharmaceutical R&D teams and fine chemical manufacturers need this material for synthesizing advanced drug candidates, where its specific stereochemistry is essential for achieving desired biological activity and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of advanced drug candidates, particularly for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of new chemical entities (NCEs) where the quinuclidine and tetrahydroisoquinoline pharmacophores are required.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in the development of stereoselective synthetic routes due to its defined [R-(R*,R*)] configuration.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory filings in pharmaceutical manufacturing.
• Preclinical & Clinical Trial Material: Supplied under GMP guidelines for the production of materials required for toxicology studies and early-phase clinical trials.

Basic Information

Item	Detail
Product Name	1(S)-Phenyl-1,2,3,4-Tetrahydroisoquinoline-2-Carboxylic Acid 3(R)-Quinuclidinyl Ester Monosuccinate ([R-(R*,R*)]-Isomer, Monohcl Salt)
CAS No.	180468-37-5
Molecular Formula	C29H34N2O6 • HCl
Molecular Weight	543.05 g/mol (for the monohydrochloride salt)
Synonyms	(R-(R*,R*))-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 3-quinuclidinyl ester monosuccinate monohydrochloride; 1(S)-Phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylic acid 3(R)-quinuclidinyl ester monosuccinate hydrochloride; Quinuclidinyl tetrahydroisoquinolinecarboxylate succinate hydrochloride; CAS 180468-37-5; (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate monosuccinate hydrochloride (stereoisomer)
EINECS	Contact for details

Quality Control

Our 1(S)-Phenyl-1,2,3,4-Tetrahydroisoquinoline-2-Carboxylic Acid 3(R)-Quinuclidinyl Ester Monosuccinate ([R-(R*,R*)]-Isomer, Monohcl Salt) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and stereochemical purity compliant with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee ([R-(R*,R*)]-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.