Description

Paclitaxel-(2-Benzoyl Ring-Ul-14C) is a carbon-14 radiolabeled derivative of the potent anticancer agent Paclitaxel, specifically labeled on the 2-benzoyl ring. This compound is an essential tool for conducting advanced absorption, distribution, metabolism, and excretion (ADME) studies in pharmaceutical research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in oncology drug discovery and metabolic pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the metabolic fate and bioavailability of Paclitaxel and its analogs in preclinical models.
• Quantitative Whole-Body Autoradiography (QWBA): Used to visualize and quantify the tissue distribution of the radiolabeled compound.
• Mass Balance Studies: Critical for determining the excretion pathways and total recovery of a drug candidate in compliance with regulatory guidelines.
• Metabolite Identification: Enabling the structural elucidation of Paclitaxel metabolites using advanced techniques like LC-MS/MS.
• Mechanistic Research: Investigating drug-target interactions, cellular uptake, and resistance mechanisms in cancer cell lines.
• Toxicology and Safety Assessment: Supporting studies to understand the long-term biodistribution and potential site-specific toxicity of therapeutics.

Basic Information

Product Name	Paclitaxel-(2-Benzoyl Ring-Ul-14C)
CAS No.	179795-24-5
Molecular Formula	C47H51NO14 (with 14C label)
Molecular Weight	~853.9 g/mol (unlabeled)
Synonyms	14C-Paclitaxel (2-Benzoyl Ring Labeled)
Carbon-14 Labeled Paclitaxel
Paclitaxel (benzoyl-UL-14C)
Taxol (2-Benzoyl-UL-14C)
[14C]-Paclitaxel
NSC 125973 (radiolabeled)
(2α,4α,5β,7β,10β,13α)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate (14C labeled)
EINECS	Contact for details

Quality Control

Every batch of Paclitaxel-(2-Benzoyl Ring-Ul-14C) is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity and specific activity to meet the exacting standards of preclinical research. Comprehensive testing includes HPLC for chemical and radiochemical purity, NMR for structural confirmation, and specific activity determination. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data including purity, specific activity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dry, inert atmosphere. Follow all applicable laboratory safety and radiation safety protocols for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solution formats)	Ethanol, Methanol, or specified solvent
Concentration	As per customer requirement (µCi/mL or mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.