Description

(2R,3R)-3-Hydroxy-3-Methyl CAS NO 179125-68-9 is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its defined stereochemistry makes it a critical precursor for the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. This compound is essential for research and production in the pharmaceutical and fine chemical industries, where precise molecular configuration is paramount for efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry influences biological activity.
• Fine Chemical Production: Serves as a versatile building block for creating complex, high-value specialty chemicals and flavors & fragrances.
• Academic & Industrial R&D: Employed in chemical research for methodological development in stereoselective synthesis and catalysis studies.
• Bioconjugate Chemistry: Potential use in the synthesis of labeled compounds or probes for diagnostic applications due to its functional handle for further modification.

Basic Information

Product Name	(2R,3R)-3-Hydroxy-3-Methyl CAS NO 179125-68-9
CAS No.	179125-68-9
Molecular Formula	C4H8O2
Molecular Weight	88.11 g/mol
Synonyms	(2R,3R)-3-Hydroxy-3-methylbutanoic acid; (2R,3R)-3-Hydroxy-3-methylbutyric acid; (2R,3R)-3-Methyl-3-hydroxybutanoic acid; (2R,3R)-HMBA; (2R,3R)-3-Hydroxy-3-methylbutanoate; (2R,3R)-3-Hydroxyisovaleric acid; (2R,3R)-3-Hydroxy-3-methylbutyrate; (2R,3R)-3-Hydroxy-3-methylbutanoic acid lactone (for cyclic form)
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-Hydroxy-3-Methyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity, typically exceeding 98.0% chemical purity and 99.0% enantiomeric excess (e.e.). Certificates of Analysis (COA) detailing specifications such as assay, chiral purity, residual solvents, and related substances are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.