Description

1-Palmitoyl(D31)-2-Oleoyl-Sn-Glycero-3-Phosphocholine is a deuterated phospholipid, specifically a perdeuterated palmitoyl chain variant of POPC. This compound is a critical tool for advanced biophysical research, offering enhanced stability and unique spectroscopic properties for probing membrane dynamics. It is essential for scientists in structural biology, pharmaceutical development, and lipidomics who require isotopically labeled lipids for techniques like NMR spectroscopy, neutron scattering, and mass spectrometry.

Application

• Membrane Biophysics & NMR Studies: Used as a deuterated probe to investigate lipid bilayer structure, dynamics, and protein-lipid interactions via 2H NMR.
• Neutron Scattering & Reflectometry: Serves as a key component in model membranes for contrast variation studies due to its distinct neutron scattering length.
• Lipidomics & Mass Spectrometry: Acts as a high-purity internal standard or reference compound for the quantitative analysis of phosphatidylcholines in complex biological samples.
• Drug Delivery System Research: Incorporated into liposomal and nanoparticle formulations to study carrier stability, biodistribution, and release mechanisms using isotopic tracing.
• Biomimetic Membrane Modeling: Used to create stable, well-defined model membranes (e.g., vesicles, supported lipid bilayers) for functional studies of membrane proteins and channels.
• Pharmaceutical R&D: Employed in the development and characterization of lipid-based therapeutics to understand formulation behavior and interaction with biological systems.

Basic Information

Product Name	1-Palmitoyl(D31)-2-Oleoyl-Sn-Glycero-3-Phosphocholine
CAS No.	179093-76-6
Molecular Formula	C42H47D31NO8P
Molecular Weight	~786.3 g/mol (for deuterated form)
Synonyms	POPC-d31; 1-Palmitoyl(d31)-2-oleoyl-sn-glycero-3-phosphocholine; Deuterated POPC; 16:0(d31)-18:1 PC; 1-Perdeuteriopalmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl 2-(trimethylazaniumyl)ethyl phosphate (with deuterated palmitoyl); D31-POPC; Phosphatidylcholine-d31 (16:0/18:1)
EINECS	Contact for details

Quality Control

Our deuterated lipids are produced under stringent conditions to ensure the highest isotopic and chemical purity for research applications. Each batch of 1-Palmitoyl(D31)-2-Oleoyl-Sn-Glycero-3-Phosphocholine is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm deuteration level, chemical identity, and purity. Certificates of Analysis (COA) detailing lot-specific data are provided to guarantee reproducibility and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maintain stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Deuteration Degree (MS/NMR)	≥ 98 atom % D (on palmitoyl chain)
Purity (HPLC)	≥ 98%
Chemical Purity (TLC)	Single spot
Solubility	Soluble in chloroform, methanol, ethanol; forms liposomes in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.