Description

Capravirine is a potent and selective non-nucleoside reverse transcriptase inhibitor (NNRTI) with significant antiviral activity. This compound is a key intermediate in the research and development of novel antiretroviral therapies targeting HIV-1. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced antiviral agents. The material is supplied to support critical drug discovery and process development efforts.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment.
• Antiviral Research: Used as a reference standard and active compound in biochemical assays to study HIV-1 reverse transcriptase inhibition mechanisms.
• Medicinal Chemistry: Serves as a core scaffold for the design and optimization of new chemical entities with improved efficacy and resistance profiles against HIV.
• Process Development: Employed in scaling up and optimizing synthetic routes for the commercial production of antiviral active pharmaceutical ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.

Basic Information

Product Name	Capravirine
CAS No.	178979-85-6
Molecular Formula	C₂₂H₂₀F₃N₅O
Molecular Weight	427.42 g/mol
Synonyms	AG-1549; S-1153; 5-(3,5-Dichlorophenyl)thio-4-isopropyl-1-(4-pyridyl)methyl-1H-imidazol-2-ylmethyl carbamate; 1-[(4-Pyridinyl)methyl]-5-[(3,5-dichlorophenyl)thio]-4-(1-methylethyl)-N-(aminocarbonyl)-1H-imidazole-2-methanamine; Capravirin; Capravirine (AG1549)
EINECS	Contact for details

Quality Control

Our Capravirine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.