Description

4-Oh-E2-1-N7Gua CAS NO 178971-91-0 is a specialized guanine derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical intermediate and reference standard for studying nucleic acid modifications, epigenetic mechanisms, and related metabolic pathways. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in the synthesis of novel therapeutic agents and high-precision analytical methods.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analogs and targeted therapeutics.
• Biochemical Research: Used as a reference standard and probe in studies of DNA/RNA oxidation, repair mechanisms, and epigenetic markers.
• Diagnostic Development: Serves as a calibrant or antigen in the development of immunoassays and LC-MS/MS methods for biomarker detection.
• Analytical Chemistry: High-purity standard for method development and validation in chromatographic (HPLC, UPLC) and mass spectrometric analyses.
• Life Science Reagents: Component in specialized kits and reagents for studying oxidative stress and cellular damage.

Basic Information

Product Name	4-Oh-E2-1-N7Gua
CAS No.	178971-91-0
Molecular Formula	C11H13N5O4
Molecular Weight	279.25 g/mol
Synonyms	4-Hydroxyestradiol-1-N7-guanine; 4-OH-E2-1-N7-Gua; 1,N7-Ethenoguanine derivative; 4-Hydroxyestradiol-derived guanine adduct; 4-Hydroxyestradiol-1,N7-guanine; 4-OH-E2-N7-Gua; 178971-91-0; Estrogen-derived guanine adduct
EINECS	Contact for details

Quality Control

Our 4-Oh-E2-1-N7Gua is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.