Description

Adenosine-2 8-3H 5'-Diphosphate is a tritium-labeled derivative of adenosine diphosphate (ADP), a critical nucleotide involved in cellular energy transfer and signaling. This radiolabeled compound is essential for high-sensitivity research, enabling precise tracking and quantification of biochemical processes. It is primarily utilized by researchers in pharmaceutical development, biochemistry, and molecular biology for studies on enzyme kinetics, receptor binding, and metabolic pathways.

Application

• Enzyme Kinetics Research: Used as a radiolabeled substrate or ligand in assays for kinases, ATPases, and other nucleotide-binding enzymes.
• Metabolic Pathway Tracing: Enables the study of energy metabolism, including ATP synthesis and utilization in mitochondria and cellular systems.
• Receptor Binding Studies: Serves as a high-affinity tracer for purinergic receptors (P2Y receptors) to investigate signaling mechanisms and screen potential drug candidates.
• Biochemical Assay Development: A key component in the development of sensitive radioimmunoassays (RIA) and scintillation proximity assays (SPA).
• Academic & Pharmaceutical R&D: Supports fundamental research in cell biology and the discovery phase of drug development programs targeting metabolic disorders.

Basic Information

Product Name	Adenosine-2 8-3H 5'-Diphosphate
CAS No.	178603-74-2
Molecular Formula	C10H14N5O10P2 * 3H
Molecular Weight	Approx. 429.2 g/mol (unlabeled)
Synonyms	Adenosine-2,8-3H-5'-Diphosphate; [2,8-3H]ADP; Tritiated ADP; Adenosine 5'-(trihydrogen diphosphate), 2,8-3H-labeled; 5'-ADP-2,8-3H; [2,8-3H]Adenosine 5'-diphosphate
EINECS	Contact for details

Quality Control

Every batch of Adenosine-2 8-3H 5'-Diphosphate is manufactured and tested to meet exacting standards for radiochemical purity and specific activity. Our quality assurance includes rigorous analytical controls such as HPLC and radiometric detection to ensure product integrity and performance consistency. Certificates of Analysis (COA) detailing specific activity, radiochemical purity, and chemical purity are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at or below -20°C in the original solvent as supplied. Avoid repeated freeze-thaw cycles. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	Clear solution
Specific Activity	Contact for details (Typical range: 20-40 Ci/mmol)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Concentration	1 mCi/mL (approx.)
Solvent	Ethanol:Water mixture

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.