Description

Benzoic Acid, 4-Amino-2,5-Difluoro-3-(Hydroxymethyl)- (9Ci) is a high-purity, multifunctional aromatic compound characterized by its unique substitution pattern of amino, fluoro, and hydroxymethyl groups. This molecular architecture makes it a versatile and valuable building block for advanced organic synthesis, particularly in the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily sought after by pharmaceutical R&D teams, agrochemical manufacturers, and fine chemical synthesis specialists who require precise and reliable intermediates for their proprietary processes.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in fluorinated pharmaceutical compounds where the fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a crucial precursor for developing new-generation herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Liquid Crystal Materials: Used in the research and production of advanced fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Acts as a building block for electron-transport materials or emissive layers in OLED (Organic Light-Emitting Diode) research.
• Complex Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Bioconjugation & Probe Development: The reactive functional groups (amino and hydroxymethyl) make it suitable for creating fluorescent probes or bioconjugation linkers for diagnostic applications.

Basic Information

Product Name	Benzoic Acid, 4-Amino-2,5-Difluoro-3-(Hydroxymethyl)- (9Ci)
CAS No.	178444-97-8
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	4-Amino-2,5-difluoro-3-(hydroxymethyl)benzoic acid; 3-(Hydroxymethyl)-4-amino-2,5-difluorobenzoic acid; 2,5-Difluoro-4-amino-3-hydroxymethylbenzoic acid; Benzoic acid, 4-amino-2,5-difluoro-3-(hydroxymethyl)-; 4-Amino-2,5-difluoro-3-(hydroxymethyl)benzoate; AFHB (abbreviation); 178444-97-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of Benzoic Acid, 4-Amino-2,5-Difluoro-3-(Hydroxymethyl)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical specifications. Our quality system is designed to support cGMP and ISO 9001 standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.