Description

Benzoic Acid, 4-Amino-2,5-Difluoro-3-Methyl- (9Ci) is a high-purity, multi-functional aromatic building block characterized by its unique substitution pattern. This compound matters as a critical intermediate for synthesizing advanced pharmaceutical agents and specialty agrochemicals, where its fluorine and amino groups enable precise molecular tuning. It is primarily needed by research and development chemists, process scale-up engineers, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a crucial building block for next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated aromatic cores for advanced electronic display materials and organic light-emitting diodes (OLEDs).
• Dye & Pigment Intermediate: Employed in the production of specialized, high-performance dyes and pigments where the amino and fluorine substitutions alter color fastness and spectral properties.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for engineering polymers with specific thermal, chemical, or surface properties.
• Research & Development: An essential tool for medicinal chemistry and material science research, enabling structure-activity relationship (SAR) studies and the exploration of new chemical entities.

Basic Information

Product Name	Benzoic Acid, 4-Amino-2,5-Difluoro-3-Methyl- (9Ci)
CAS No.	178444-92-3
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	4-Amino-2,5-difluoro-3-methylbenzoic acid; 2,5-Difluoro-4-amino-3-methylbenzoic acid; 3-Methyl-4-amino-2,5-difluorobenzoic acid; Benzoic acid, 4-amino-2,5-difluoro-3-methyl-; 178444-92-3; 4-Amino-2,5-difluoro-3-methyl-benzoic acid; 2,5-Difluoro-3-methyl-4-aminobenzoic acid
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-Amino-2,5-Difluoro-3-Methyl- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider packaging under an inert gas such as nitrogen or argon. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.