Description

2-Fluoro-4-Biphenylylboronic Acid is a high-value organoboron building block, specifically a biphenyl-substituted boronic acid derivative. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures in modern synthetic chemistry. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of drug candidates, particularly those containing complex biphenyl or heterobiaryl scaffolds.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by constructing specific aromatic frameworks.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in catalysis and molecular recognition.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological mechanisms.
• Custom Synthesis and Contract Manufacturing: An essential building block for custom chemical synthesis services targeting high-value, low-volume specialty chemicals.

Basic Information

Product Name	2-Fluoro-4-Biphenylylboronic Acid
CAS No.	178305-99-2
Molecular Formula	C12H10BFO2
Molecular Weight	216.02 g/mol
Synonyms	(2-Fluoro[1,1'-biphenyl]-4-yl)boronic Acid; 2-Fluoro-4-phenylphenylboronic Acid; 4-Borono-2-fluorobiphenyl; 2-Fluoro-4-biphenylboronic Acid; [1,1'-Biphenyl]-4-boronic acid, 2-fluoro-; 2-Fluoro[1,1'-biphenyl]-4-ylboronic Acid; 2-Fluoro-4-biphenylyl-B(OH)2
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Biphenylylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (as Boronic Acid)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.