Description

Rac-Efavirenz CAS NO 177530-93-7 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) primarily used as a key intermediate in the research and development of antiviral pharmaceuticals. This compound is critical for ensuring the quality and consistency of active pharmaceutical ingredients (APIs) targeting HIV-1. It is an essential raw material for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on antiretroviral therapy development and quality control.

Application

• Pharmaceutical Intermediate: Serves as a critical starting material or intermediate in the synthesis of the active pharmaceutical ingredient Efavirenz.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing of Efavirenz APIs and finished dosage forms.
• Research & Development: Employed in preclinical and clinical research to study the metabolism, pharmacokinetics, and efficacy of NNRTI-class antiviral drugs.
• Impurity Profiling: Utilized as a marker to identify, quantify, and control related substances and enantiomeric impurities during the manufacturing process of Efavirenz.
• Process Chemistry: Applied in the development and optimization of synthetic routes for antiviral drug production, including chiral separation studies.

Basic Information

Product Name	Rac-Efavirenz
CAS No.	177530-93-7
Molecular Formula	C14H9ClF3NO2
Molecular Weight	315.67 g/mol
Synonyms	(±)-Efavirenz; Racemic Efavirenz; (±)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (±)-; DMP 266 (racemate); Sustiva Intermediate (racemic); EFV (racemic mixture)
EINECS	Contact for details

Quality Control

Our Rac-Efavirenz is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≤ 2.0% (Total enantiomeric impurity)
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.