Description

Ambrisentan is a potent and selective endothelin receptor antagonist (ERA) used in the treatment of pulmonary arterial hypertension (PAH). Its high selectivity for the endothelin type-A (ETA) receptor helps to inhibit the pathological vasoconstriction and vascular remodeling associated with the disease. This active pharmaceutical ingredient (API) is critical for pharmaceutical manufacturers developing and producing targeted therapies for cardiovascular and pulmonary conditions. The compound is supplied under the identifier Ambrisentan CAS NO 177036-94-1.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of Pulmonary Arterial Hypertension (PAH).
• Clinical Research: Serves as a reference standard and key material in preclinical and clinical studies for cardiovascular diseases.
• Formulation Development: Used in R&D for developing new drug delivery systems, such as tablets and other oral formulations.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent generic versions of branded PAH medications.
• Biochemical Research: A tool compound for studying endothelin receptor signaling pathways and vascular biology in laboratory settings.

Basic Information

Product Name	Ambrisentan
CAS No.	177036-94-1
Molecular Formula	C22H22N2O4
Molecular Weight	378.42 g/mol
Synonyms	Ambrisentan; BSF 208075; LU 208075; 2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid; (2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid; Letairis (Brand Name); Volibris (Brand Name)
EINECS	Contact for details

Quality Control

Our Ambrisentan is manufactured under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is tested against rigorous specifications for identity, purity, and potency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from tests including HPLC assay, related substances, residual solvents, and heavy metals. We support compliance with ICH Q7 guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.