Description

4Chloro3Trifluoromethoxyphenylboornicacid CAS NO 176976-42-2 is a high-purity organoboron compound, specifically a boronic acid derivative, serving as a critical building block in advanced chemical synthesis. Its value lies in its unique molecular structure, which combines halogen and trifluoromethoxy substituents to impart specific reactivity and stability for creating complex molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients through cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogenated aromatic structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Utilized as a handle for bioconjugation and in the synthesis of molecular probes and inhibitors for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: An important starting material for fine chemical producers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	4Chloro3Trifluoromethoxyphenylboornicacid
CAS No.	176976-42-2
Molecular Formula	C8H5BClF3O3
Molecular Weight	251.38 g/mol
Synonyms	4-Chloro-3-(trifluoromethoxy)benzeneboronic acid; (4-Chloro-3-(trifluoromethoxy)phenyl)boronic acid; 4-Chloro-α,α,α-trifluoro-m-tolylboronic acid (ambiguous); B-[4-Chloro-3-(trifluoromethoxy)phenyl]boronic acid; 4-Chloro-3-trifluoromethoxybenzeneboronic acid; 4-Chloro-3-trifluoromethoxyphenylboronic acid; 176976-42-2 (CAS).
EINECS	Contact for details

Quality Control

Our 4Chloro3Trifluoromethoxyphenylboornicacid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with customer requirements for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.