Description

9-(2-Methylidene-3-(Phosphonomethoxy)Propyl)Guanine is a chemically modified nucleoside analogue with a phosphonomethoxypropyl side chain, representing a significant class of antiviral prodrugs. This compound is valued for its role as a key synthetic intermediate in the development of nucleotide-based therapeutics, particularly antiviral agents targeting viral polymerases. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antiviral drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleotide analogue antiviral drugs, such as acyclic nucleoside phosphonates.
• Antiviral Research: Used in biochemical and virological studies to investigate mechanisms of action against DNA viruses, including herpesviruses and hepatitis B virus.
• Prodrug Development: Serves as a precursor molecule for designing and optimizing prodrugs with enhanced oral bioavailability and cellular uptake.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop novel antiviral agents with improved potency and selectivity.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory filings in pharmaceutical manufacturing.
• Bioconjugation Studies: The reactive methylidene and phosphonate groups allow for further chemical modifications and linker attachments in bioconjugate chemistry.

Basic Information

Product Name	9-(2-Methylidene-3-(Phosphonomethoxy)Propyl)Guanine
CAS No.	176434-89-2
Molecular Formula	C10H14N5O5P
Molecular Weight	315.22 g/mol
Synonyms	PMEG Guanine Derivative; (2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-(phosphonomethoxy)propylidene)guanine; 9-[2-[(Phosphonomethoxy)ethyl]prop-2-en-1-yl]guanine; Acyclic Nucleoside Phosphonate Guanine Analogue; ANP Guanine; PMEG Precursor; Guanine, 9-[2-[(phosphonomethoxy)ethyl]-2-propen-1-yl]-; 9-(2-Methylene-3-(phosphonomethoxy)propyl)guanine
EINECS	Contact for details

Quality Control

Our 9-(2-Methylidene-3-(Phosphonomethoxy)Propyl)Guanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry characterization. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.