Description

(2S,3S,4R,5S)-2-(2-Amino-5,6-Dichloro-1H-Benzo[D]Imidazol-1-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol is a high-purity nucleoside analog derivative, a key building block in advanced pharmaceutical research and development. This compound is valued for its precise stereochemistry and functional groups, which are critical for designing novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of antiviral drugs, anticancer compounds, and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and molecular biology research targeting DNA/RNA processes.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteomics & Genomics: Potential utility in the development of probes or tools for studying genetic expression and protein interactions.
• Contract Manufacturing (CMO): Supplied to custom synthesis organizations for the production of Active Pharmaceutical Ingredients (APIs) under GMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic chemistry and pharmacology.

Basic Information

Product Name	(2S,3S,4R,5S)-2-(2-Amino-5,6-Dichloro-1H-Benzo[D]Imidazol-1-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol
CAS No.	176161-52-7
Molecular Formula	C₁₃H₁₄Cl₂N₄O₄
Molecular Weight	361.18 g/mol
Synonyms	2-Amino-5,6-dichloro-1-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-benzo[d]imidazole; 5,6-Dichloro-2-amino-1-β-D-ribofuranosylbenzimidazole (Carbocyclic analog); DZ1; TCRB Intermediate; 1-(β-D-Ribofuranosyl)-2-amino-5,6-dichlorobenzimidazole derivative; 2-AADCB; Benzimidazole nucleoside derivative CAS 176161-52-7
EINECS	Contact for details

Quality Control

Our (2S,3S,4R,5S)-2-(2-Amino-5,6-Dichloro-1H-Benzo[D]Imidazol-1-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol is produced under strict quality management systems. We offer material suitable for research and development, with specifications tailored to client requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each batch. For GMP-grade material intended for advanced pharmaceutical applications, comprehensive documentation and additional testing are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.