Description

Boc-Tryptophan Nca CAS NO 175837-77-1 is a protected amino acid derivative, specifically the N-carboxyanhydride (NCA) of Boc-L-tryptophan. This compound serves as a critical, high-purity building block for the controlled synthesis of polypeptides and complex biomaterials via ring-opening polymerization. It is essential for researchers and manufacturers in advanced pharmaceutical development, particularly for creating novel peptide-based therapeutics and drug delivery systems where precise sequence control and functional group protection are paramount.

Application

• Peptide & Polypeptide Synthesis: A key monomer for the ring-opening polymerization (ROP) synthesis of well-defined polypeptides and block copolymers.
• Pharmaceutical Research: Used in the development of novel peptide drugs, prodrugs, and bioactive conjugates requiring tryptophan incorporation with side-chain protection.
• Biomaterials Engineering: Enables the creation of functionalized, biodegradable polymers for drug delivery vehicles, tissue engineering scaffolds, and diagnostic agents.
• Chemical Biology: Acts as a specialized reagent for introducing the tryptophan moiety into synthetic peptides under mild conditions while maintaining the Boc-protecting group.
• Advanced Material Science: Facilitates the production of smart polymers with specific optical or electronic properties derived from the indole side chain.

Basic Information

Product Name	Boc-Tryptophan Nca
CAS No.	175837-77-1
Molecular Formula	C₁₉H₂₂N₂O₅
Molecular Weight	358.39 g/mol
Synonyms	Boc-L-Tryptophan N-Carboxyanhydride; Nα-Boc-L-Tryptophan NCA; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid anhydride; 1-tert-Butyl 2,5-dioxo-4-[(1H-indol-3-yl)methyl]imidazolidine-1,2-dicarboxylate; Boc-Trp-NCA; Boc-Trp-NCA monomer; Nα-(tert-Butoxycarbonyl)-L-tryptophan N-carboxyanhydride
EINECS	Contact for details

Quality Control

Every batch of Boc-Tryptophan Nca is manufactured and tested under strict quality management systems to ensure the highest standards of purity and consistency required for sensitive polymerization and pharmaceutical applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and prevent premature polymerization. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.