Description

(R)-Taclo CAS NO 175779-27-8 is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its primary value lies in its role as a key building block for the production of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical integrity is critical for efficacy and safety. This compound is essential for research and manufacturing organizations in the pharmaceutical and fine chemical industries, particularly those developing or producing advanced therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a starting material or reagent in catalytic asymmetric reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a valuable scaffold for drug discovery and lead optimization programs targeting specific biological pathways.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs).
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Fine Chemical Synthesis: Applied in the production of other high-value, specialty chemicals requiring precise stereochemical control.

Basic Information

Product Name	(R)-Taclo
CAS No.	175779-27-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-Taclo; (R)-Tacrolimus Impurity; Tacrolimus Related Compound R; (R)-Tacrolimus Intermediate; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-1-[(1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl]-3-methylbut-1-en-1-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-ene-2,3,10,16-tetrone; FK-506 Impurity R; FR-900506 Impurity R
EINECS	Contact for details

Quality Control

Our (R)-Taclo is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to confirm identity and meet stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.