Description

2-(Trifluormethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a phenyl ring substituted with both a trifluoromethoxy group and a boronic acid moiety. This unique structure makes it a valuable building block in modern synthetic chemistry, particularly for cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily utilized by pharmaceutical and agrochemical R&D teams for constructing complex molecules and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the trifluoromethoxy pharmacophore for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the phenylboronic acid group enables efficient carbon-carbon bond formation.
• Material Science Research: Serves as a monomer or linker in the development of organic electronic materials, polymers, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: An essential reagent for palladium-catalyzed coupling reactions to form biaryl structures, a common motif in many functional compounds.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for catalysis and sensing applications.
• Chemical Biology Probes: Useful for modifying biomolecules or creating probes for studying biological processes.

Basic Information

Product Name	2-(Trifluormethoxy)Phenylboronic Acid
CAS No.	175676-65-0
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	(2-(Trifluoromethoxy)phenyl)boronic acid; 2-Trifluoromethoxyphenylboronic Acid; 2-(Trifluoromethoxy)benzeneboronic Acid; B-[2-(Trifluoromethoxy)phenyl]boronic Acid; 2-CF3O-C6H4-B(OH)2; 175676-65-0; (2-Trifluoromethoxyphenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluormethoxy)Phenylboronic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing including HPLC, NMR, and elemental analysis to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.